The results of the fifth estimate of complete coverage of vaccination against covid-19 in Venezuela are reported, through questions included in a national sample survey. The survey was conducted between December 13 and 19, 2021 in population centers of 1,000 and more inhabitants. A total of 1,200 people aged 18 years and older were interviewed. Interviews were conducted in people’s homes. Complete vaccination coverage against covid-19 corresponds to 50.0% of the population aged 18 years and older in the country. The age group with the highest complete coverage is those aged 50 and over (72.3%). Complete coverage in the Metropolitan District of Caracas (MDC) is 59.07%, in the main cities 45.56%, and in the rest of the country 50.1%. Complete coverage is higher in the E socioeconomic level (63.0%). The population reporting that they do not have any vaccine dose, and want to be vaccinated, corresponds to 17.9%. And those who report that they are not vaccinated against covid-19, and do not want to be vaccinated, represent 13.4%. The proportion of the vaccinated population aged 18 years and older that received the Sinopharm and Sinovac vaccines is 72.7%. The gap of fully vaccinated population in Venezuela in persons aged 18 years and older (50%) should influence significant changes to increase coverage in the coming weeks, especially in view of the confirmation of cases of the Omicron variant.