CV. Breakthrough infections with SARS-CoV-2 Omicron variant despite booster dose of mRNA vaccine

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Constanze Kuhlmann, et al.

Recopilado por Carlos Cabrera Lozada. Miembro Correspondiente Nacional, ANM puesto 16. ORCID: 0000-0002-3133-5183. 10/12/2021

Abstract

Based on its genetic profile and preliminary in vitro and epidemiological data, the recently emerged SARS-CoV-2 Omicron variant is predicted to evade immune responses to some extent. We report a cluster of Omicron variant infections in individuals who had received full primary vaccination series and booster doses with mRNA vaccines. All patients experienced symptomatic COVID-19 but clinical manifestations were mild to moderate. Their SARS-CoV-2 viral RNA loads and anti-spike antibody levels were determined. This series proves that even three doses of mRNA vaccines may not be sufficient to prevent infection and symptomatic disease with the Omicron variant.

Keywords: SARS-CoV-2, Omicron variant, B.1.1.529, vaccine breakthrough infection, booster vaccination, COVID-19, mRNA vaccine

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